英语词汇“metyrapone”的英英意思、用法、释义、翻译、读音、例句、短语、词组、英语词典-本地帮

单词

metyrapone

释义

metyrapone Pharm.|mɛˈtɪ-, mɛˈtaɪərəpəʊn|
[f. 2-methyl-1,2-di(pyrid-3-yl)propan-1-one, the chemical name (f. methyl + di-²+ pyridyl + propane + -one), with insertion of a.]
A whitish crystalline compound, C₅H₄N·CO·C(CH₃)₂·C₅H₄N, which inhibits the synthesis of cortisone and hydrocortisone and is used for testing the function of the anterior pituitary.
1962Lancet 8 Dec. 1199/1 This paper reports the prevention of massive adrenal necrosis due to d.m.b.a. by the concurrent administration of metyrapone.1970Passmore & Robson Compan. Med. Stud. II. vi. 14/2 The metyrapone test depends upon the fact that the feedback control mechanism between the adrenal cortex and the hypothalamo–pituitary axis is mediated by the circulating concentration of unbound cortisol.1973Clin. Pharmacol. & Therapeutics XIV. 455 After 1 year of treatment urinary steroids and their responses to oral metyrapone were unchanged.

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