| 单词 | bungarotoxin |
| 释义 | bungarotoxin, n. Biochem.|ˌbʌŋgərəʊˈtɒksɪn|
[f. mod.L. Bungar-us (see bungarum n.) + -o1 + toxin n.]
Each of three neurotoxins isolated from the venom of the elapid snake Bungarus multicinctus; spec. α-bungarotoxin, which binds to acetylcholine receptors with a high degree of specificity.
1963Chang & Lee in Arch. Internat. de Pharmacodynamie et de Thérapie CXLIV. 245 For the sake of convenience, these neurotoxins will be henceforth designated as α-, β- and γ-Bungarotoxin respectively in the order of increasing electrophoretic mobility. Ibid. 255 It is concluded that α-Bungarotoxin blocks neuromuscular transmission by irreversible combination with the acetylcholine receptor in the motor end-plate whereas β- and γ-Bungarotoxins exhibit their action at pre-synaptic site(s). 1973New Scientist 1 Mar. 471/3 Using radioactive bungarotoxin (which binds specifically to ACh receptor sites), Nirenberg is able to count the number of receptors in the clusters. 1982Acta Histochem. et Cytochem. XV. 598 It is well known that crude bungarotoxin contains β-toxin which binds to the presynaptic site. 1989B. Alberts et al. Molecular Biol. Cell (ed. 2) xix. 1085 A snake paralyzes its prey by injecting α-bungarotoxin to block the nicotinic acetylcholine receptor. |
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