英语词汇“penicillinase”的英英意思、用法、释义、翻译、读音、例句、短语、词组、英语词典-本地帮

单词

penicillinase

释义

penicillinase Biochem.|pɛnɪˈsɪlɪneɪz, -s|
[f. prec. + -ase.]
Any of the enzymes (produced by certain bacteria) which cause the breaking up of the carbon-nitrogen bond in the lactam ring of some penicillins (so rendering them ineffective as antibiotics). Cf. lactamase.
1940Abraham & Chain in Nature 28 Dec. 837/1 The activity of the enzyme, which we term penicillinase, is slight at pH5, but increases considerably towards the alkaline range of pH.1958Ann. Rev. Biochem. XXVII. 176 Cephalosporin-C possesses the interesting property of being resistant to the action of some penicillinases including that produced by penicillin resistant staphylococci.1971[see lactamase].1974M. C. Gerald Pharmacol. iv. 72 Recent research has made available new penicillins that are resistant to acid hydrolysis and penicillinase attack.1975Nature 12 June 526/1 Penicillinases, or as they are now known, β-lactamases, are enzymes which specifically deactivate penicillin by hydrolysis of the β-lactam ring.

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