| 单词 | sildenafil |
| 释义 | sildenafil, n. Pharmacol.
Brit. |sɪlˈdɛnəfɪl|, U.S. |ˌsɪlˈdɛnəfɪl|
[Origin unknown.]
A piperazine derivative that acts as a selective inhibitor of cyclic nucleotide (guanosine monophosphate) phosphodiesterase, and is given orally as the citrate (more fully sildenafil citrate) to improve blood flow into the penis and enhance erectile function; 1-[[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methyl-piperazine, C22H30N6O4S.
A proprietary name for this drug is Viagra n.
1995PR Newswire (Nexis) 23 Oct. Sildenafil, for male erectile dysfunction (MED), showed a response rate as high as 90 percent in a large clinical trial of patients with a primarily psychologically based condition. 1996Brit. Jrnl. Urol. 78 257 Sildenafil, a novel orally active inhibitor of the type-V cyclic guanosine monophosphate-specific phosphodiesterase (the predominant isoenzyme in the human corpus cavernosum). 1999Irish Med. Jrnl. (Electronic ed.) 92 5 Sildenafil is absolutely contra-indicated in patients taking nitrates, whether continuous or episodic because of the severe hypotension that may result. |
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