| 单词 | primaquine |
| 释义 | primaquine Pharm.|ˈpraɪmə-, ˈpriːməkwiːn|
[f. prima2 + quinoline.]
A synthetic quinoline derivative which is used (in the form of an orange-red crystalline phosphate) in the treatment of malaria; 8-(4-amino-1-methylbutylamino)-6-methoxyquinoline, C15H21N3O.
1949Jrnl. Amer. Med. Assoc. 3 Sept. 26/2 The Malaria Study Section, Laboratory of Tropical Disease, National Institutes of Health..suggested the term ‘primaquine’, to distinguish the compound from ‘pentaquine’ and ‘iso⁓pentaquine’. 1960Times 11 Nov. 17/1 Primaquine, one of the newer and most efficient drugs for the treatment of malaria. 1962Lancet 1 Dec. 1133/1 An erythrocyte defect similar to that found in primaquine sensitivity. 1965New Scientist 19 Aug. 440/1 Medical officers at the Walter Reed Army Research Institute in Washington..report that the anti-malarial drugs, chloroquine and primaquine..are proving less and less effective. 1973B. J. Williams Evolution & Human Origins iv. 65/2 Such hemolytic reactions also occur in persons with G6PD deficiency ion response to certain drugs, including some antimalarials (receiving the terms ‘primaquine sensitivity’, etc.). 1974M. C. Gerald Pharmacol. iv. 77 Of the 15,000 compounds..screened as substitute antimalarials, only two, chloroquine and primaquine, were found to be superior to quinine. 1978Nature 22 June 627/1 The antimalarial drugs selected for the WHO list are chloroquine, primaquine, pyrimethamine and quinine. |
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