英语词汇“prodrug”的英英意思、用法、释义、翻译、读音、例句、短语、词组、英语词典-本地帮

单词

prodrug

释义

prodrug, n. Biochem. and Physiol.|ˈprəʊdrʌg|
[f. pro-² 1 + drug n.¹]
Any (usu. biologically inactive) compound which may be metabolized in vivo to produce a drug; a compound from which a given drug is metabolized.
1968Jrnl. Pharmaceutical Sci. LVII. 779/2 Carbonate and carboxylate esters prepared as potential prodrugs of acetaminophen were shown to have a variety of physicochemical properties, particularly lipid and water solubilities.1978Nature 23 Nov. 405/1 As lipid-soluble drugs rapidly pass the blood-brain barrier, we synthesised a ‘prodrug’ from ADTN.1985Jrnl. Med. Chem. XXVIII. 108/1 Results with brain tissue in vitro and in vivo suggest that the compound behaves as a ‘prodrug’ which releases its GABA activity in the CNS following hydrolysis.1989European Jrnl. Pharmacol. CLIX. 257 (heading) Antiinflammatory action of salicylates: aspirin is not a prodrug for salicylate against rat carrageenin pleurisy.

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