英语词汇“metiamide”的英英意思、用法、释义、翻译、读音、例句、短语、词组、英语词典-本地帮

单词

metiamide

释义

metiamide, n. Pharm.|mɪˈtaɪəmaɪd|
[f. meth- + -iamide, perh. f. a rearrangement of imidazole n.]
An imidazole derivative with histamine H₂ -receptor blocking properties which was formerly used to treat peptic ulcers; 1-methyl-3-(2-[5-methylimidazol-4-ylmethylthio]ethyl)thiourea, C₉H₁₆N₄S .
1973Gut XIV. 424/1 Metiamide, an analogue of burimamide, has been given intravenously to seven volunteers.1977Lancet 10 Sept. 555/2 The bone-marrow toxicity of metiamide might be related to the compound's ability to block the histamine H₂-receptor associated with the pluripotent bone-marrow stem cell. 1981M. C. Gerald Pharmacol. (ed.2) xxv. 498 Burimamide, ineffective when taken by mouth.., was succeeded in clinical trials by the orally active metiamide; trials were discontinued when metiamide was found to cause agranulocytosis.1987Agents & Actions XXII. 220/2 The TTX [sc. tetrodotoxin]-resistant responses to histamine were sensitive to mepyramine, but not metiamide.

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