单词 | pharmacophore |
释义 | pharmacophore, n. Pharmacol. Brit. |ˈfɑːməkəˌfɔː|, U.S. |ˈfɑrməkəˌfɔ(ə)r| [‹ pharmaco- comb. form + -phore comb. form, after pharmacophoric adj.] The part of a molecule that is responsible for its characteristic pharmacological activity; a pharmacologically active group.
1964Biochem. Pharmacol. 13 332 The second is a specific structural requirement for which we will use the term ‘pharmacophore’. 1971L. B. Kier Molecular Orbital Theory in Drug Res. viii. 170 The molecule is permitted to assume a pattern identical to that previously calculated for the muscarinic pharmacophore. 1977Jrnl. Medicinal Chem. 20 85 Attempts to elucidate the prolactin release inhibiting pharmacophore within the ergoline structure. 1994Chem. in Brit. Oct. 809/2 Drug design strategy..generates possible pharmacophores based on a set of biologically active compounds. 2000Denver Post 10 Sept. l27 (advt.) A dynamic drug discovery company applying the latest innovations..for identification and characterization of pharmacophores from natural products. |

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